Biology Of Disease And Therapeutics - 1386 Words

MSc Biomedical Science Edinburgh Napier University Biology of Disease and Therapeutics Coursework Part A 2015 QUESTION A - DATA HANDLING EXERCISE Below are data from a Phase 2, randomised, double-blind, placebo-controlled clinical trials, testing the effectiveness of two doses of a new drug designed to lower glucose concentrations in patients suffering from type 2 diabetes. In each trial, patients with Type 2 diabetes were randomised to receive one of two doses of drug or matching placebo once daily for 10 weeks. Whilst the drug has been well tolerated in earlier testing, it has been noted that higher doses are associated with unwanted side effects such as dizziness and nausea. Table 1. Demographics of Clinical Trial Participants (n=18) Patient details Trial drug: Napsentan Total number 18 Male 10 Female 8 Age 50-72 years Source: Fictitious data, for illustration purposes only Table 2. Trial 1 data (Napsentan) Group Plasma glucose (fasting) before treatment (mmol/l) Plasma glucose (fasting) after treatment (mmol/l) Placebo (n =6) 7.32 7.28 7.42 7.36 7.68 7.54 8.10 7.89 7.96 8.02 7.63 7.56 100 mg Napsentan (n = 6) 7.52 6.15 7.34 6.32 8.14 6.08 7.66 6.53 7.58 6.32 7.92 6.05 300 mg Napsentan (n = 6) 7.36 6.02 7.34 6.31 7.65 6.02 8.21 6.46 7.12 6.04 7.03 6.11 Source: Fictitious data, for illustration purposes only QUESTION A A1. Explain why it is important to have randomised, double-blind, placebo-controlled clinicalShow MoreRelatedThe Use Of Biosynthetic Organisms761 Words   |  4 PagesEach time a new human disease is discovered, the scientific community attempts to find a way to cure it. The success of almost all medicines can be found in their molecular mechanisms. It is not abnormal for therapies to alter the way the human body or an invasive organism functions. 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